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An overview of RAS protein mutations in cancer and KRAS-targeted therapeutics

RAS proteins are present in all mammalian cells where they act as signal transducers for pathways regulating cell growth, proliferation, differentiation, and survival. More than 150 human RAS proteins have been identified to-date. Mutations in this protein family have been found to drive more than 30% of all human cancers. The KRAS isoform is of …

Choosing the Right Technology for Your Polymer Testing Needs

Polymers are in use in almost every industry today. With such a wide variety put to use in many different ways, testing needs will also vary across the board. Understanding which technologies are applicable to your industry and your stage in the polymer production lifecycle is vital to meeting your analytical needs. Many technologies can …

India Rare Disease Conference

Emerging economies have shown success in addressing child health issues such as infections, malnutrition, and diarrhea. However, to further improve infant and child mortality rates, newborn screening should be adopted. Hundreds of thousands of babies each year worldwide could avoid a lifetime of disability or even death with the implementation of screening tools. Unfortunately, not …

VIDEO Q&A: A Macro View at Microplastics in Water

A chat with Professor Pennie Lindeque, Plymouth Marine Laboratory, UK. The term “microplastics” was first introduced in 2004 and refers to any type of plastic fragment that is less than 5 mm in length. That’s smaller than the number printed on the front of a credit card. There are two types of microplastics – primary …

Getting a research program up and running isn’t easy. Here are some opportunities for ambitious scientists who want to be confident in their lab set up or need the use of a new instrument to boost their research. Lab Start-Up Program Asking the right questions early on is one of the crucial steps to building …

In Vivo Imaging Study Highlights Potential for Non-Invasive NASH Diagnosis

Nonalcoholic steatohepatitis (NASH) is a chronic yet silent disease, and patients present with few or no symptoms at early stages. The condition affects around 12% of the US population and there are currently no treatments available for those affected. NASH is also expected to be the leading cause of liver transplantation in the near future. …

Win the Race with These Rapid Chemical Kinetics Techniques

Chemical kinetics, the study of the rates and mechanisms of reactions, is an indispensable tool in both chemical discipline development and scientific research. With it, researchers can tell whether a reaction can occur, how fast it will happen, and how to control the speed. With applications in both basic and applied sciences, chemical kinetics lets …

How to Accelerate Semiconductor Manufacturing

Semiconductors have helped move innovation forward, from advancing the first space travel to the first autonomous vehicle-they are a powerful technology. They are widely used in many products we use and depend on every day, from smartphones and computers to transportation and industrial manufacturing. Advances in semiconductors have touched every aspect of our lives and …

One of the major challenges in oncology research today is the ability of tumors to evolve drug resistance. For researchers in the field, tackling cancer resistance can be a frustrating and somewhat unrewarding pursuit. During tumor progression, distinct cell populations with different molecular and phenotypic profiles start to form. The more heterogenous the tumor is …

Novel Assay for Simultaneous Measurement of bsAb Target Binding

Over the last three decades we’ve seen significant advances in the development and commercialization of therapeutic antibodies across numerous indications, including many cancers, as well as infectious, autoimmune, and metabolic diseases. During this time, the industry has grown exponentially and is now valued at billions of dollars. The first monoclonal antibody was approved by the …

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