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3D Cellular Imaging in Pre-clinical Drug Development

The pre-clinical drug development workflow includes toxicity evaluation at iteratively higher biological levels: cellular, tissue, organ, and whole organism. The ability to model and image at each of these levels is a powerful tool for molecule evaluation and development. Ex vivo 3D cellular modeling and imaging is a valuable early step in a candidate molecule’s …

Antibody therapies have become an important tool in treating diverse conditions such as autoimmune diseases, cardiovascular diseases, allergic conditions, infectious diseases, and cancers. Proven methods for developing such antibody therapies include using mice with genetically humanized immune systems and human B cells to produce fully human antibodies. These approaches have recently been used to develop …

As the effects of the novel virus are felt worldwide, researchers across the globe are mobilizing to find anti-viral therapies to fight against this new infection. Tackling this challenge by traditional de novo drug discovery approaches is a critical piece of the puzzle but also demands time and sizable investments. As an alternative approach, screening …

With the current global pandemic, tests for detecting antibodies against SARS-CoV-2 have become widely available. These tests are used to determine if a person has been exposed to the virus and can suggest whether they have developed immunity. Traditional wash-based ELISA assays are the most prevalent assay format used for these tests. Detection of anti-virus …

Finding a best-fit or combination of pre-clinical models in immuno-oncology drug development poses a unique series of challenges. Foundational knowledge of the tumor microenvironment and its evasion of the immune system continues to evolve based on emerging data from areas including regulation, academia, and industry. When functioning under homeostatic conditions, the immune system exhibits immunosurveillance …

A Quiet Revolution The nanotech world just witnessed a revolution. For the first time in history, scientists at the University of South Carolina’s Center for Environmental NanoScience and Risk (CENR) and PerkinElmer have precisely quantified the uptake of metal nanoparticles by individual cells. Using PerkinElmer’s innovative NexION® Single Cell Inductively Coupled Plasma Mass Spectrometer (SC-ICP-MS), …

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