Identifying, counting, and performing quantitative measurements on cells or cellular responses throughout discovery and development workflows can be challenging. This is because the varying complexities of biological sources involved in studies and treatments require individualized and optimized conditions, formulations, and specialized bioprocessing steps that are dependent on their intended use. Achieving optimization requires consideration of …

Laboratory professionals in all areas of science have experienced significant changes in recent years, and 2022 was no exception. As steady progress continues in returning to normalcy as we’ve learned how to manage COVID-19, the emergence of mpox last year brought a new set of challenges for healthcare professionals, laboratories and diagnostics developers to navigate. …

Immunotherapy has revolutionized cancer treatment and proved to be pivotal in the field of oncological research. Among several immunotherapeutic approaches that have been pursued, inhibiting the PD-1 (programmed cell death protein-1)/PD-L1 pathway has gained increased attention in recent years and shown exciting clinical success in a range of human cancers. Under normal circumstances, interactions between …

Bispecific antibodies (BsAb) are promising biotherapeutics for an increasing range of diseases. There are currently seven BsAb approved by the U.S. Food and Drug Administration (FDA) and/or the European Medicines Agency (EMA) for a range of indications: Relapsed or refractory precursor B-cell acute lymphoblastic leukemia Bleeding due to hemophilia A Non-small cell lung cancer Unresectable …

Earlier this year, the World Health Organization (WHO) announced that over one million African children had received one or more doses of the world’s first malaria vaccine, RTS,S/AS01 (RTS,S).1 If widely deployed, the WHO estimates that the vaccine, which is the result of 30 years of research, could save the lives of an additional 40,000 …

The current SARS-CoV-2 pandemic has highlighted the substantial threat posed by pathogenic coronaviruses to humans. To date, over six million people have died from COVID-19 across the globe and more than 500 million cases have been reported.1 Although effective COVID-19 vaccines have been developed, variants of SARS-CoV-2 have already emerged for which vaccines are less …

The potential to harness an individual’s immune system to treat cancer has revolutionized the oncology field. Coined immunotherapy, this umbrella term describes several types of treatment, including immune checkpoint inhibitors, immune system modulators, and adoptive cell therapies. Each triggers the immune system in a different way to fight cancer. One approach currently being explored involves …

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. Millions of people are affected by these conditions across the globe, and with improved life expectancy in many parts of the world, it is likely that incidence will …

In early 2019, no one could have predicted that a novel coronavirus would sweep around the globe and cause one of the most significant health crises of recent times. Fast-forward to today, and thousands of scientists have turned their attention to studying SARS-CoV-2, the virus responsible for the current COVID-19 pandemic. This research pivot led …

A Global Scourge  Around 50 million people worldwide currently suffer from one or more forms of dementia. Of these, around 850,000 live in the United Kingdom (UK) at an annual care cost of £26 billion (US$38 billion). Unless something is done, experts predict these numbers will likely double within the next 20 years.1 To address …