Over the last three decades we’ve seen significant advances in the development and commercialization of therapeutic antibodies across numerous indications, including many cancers, as well as infectious, autoimmune, and metabolic diseases. During this time, the industry has grown exponentially and is now valued at billions of dollars. The first monoclonal antibody was approved by the …
The speed at which researchers developed effective vaccines to prevent the spread of COVID-19 required unprecedented international cooperation on a scale never seen before. Rollout of approved vaccines is underway in many countries across the globe, giving people hope that the end to the pandemic is finally in sight. Meanwhile, researchers are continuing to investigate …
Targeted cancer therapy has been a game changer in cancer treatment, significantly improving the survival and quality of life of many patients. Unlike chemotherapy, which acts on both cancer and normal cells, targeted therapy affects only the specific oncogenes, tumor suppressor genes, or pathways involved in tumor progression. Despite the success of targeted cancer therapy, …
Laboratories rely on microplate readers to translate experimental observations into raw data in order to process and analyze results. Microplate readers detect signals within assays, turning the targeted biological, chemical or physical signal into an optical signal so researchers can quantify the target of interest. Using a microplate reader is efficient and minimizes operational time …
The success of drug discovery labs lies in optimized workflows. Countless hours and valuable resources are often spent on physically preparing and loading plates into readers-that time could be spent analyzing data or researching a novel, potentially breakthrough target. There’s a constant hunt for new, effective vaccines that could replace current, commonly used ones that …
Antibody therapeutics have grown in complexity over their 30-year history in clinical application. Newer generation antibody therapies target multiple modalities and are multi-specific in nature. A multi-specific protein therapeutic can function as an alternative to a cell therapy. For example, an antibody can be engineered to target a T cell receptor and a tumor receptor …
Improved cellular imaging technologies are providing researchers with more robust datasets while maintaining high data quality. While this is a plus for drug discovery workflows, it also presents its own challenges: how to evaluate the large datasets in a timely manner and obtain deeper insights from the expanded data. Artificial intelligence is providing a way …
Industry leaders reveal how high throughput screening is changing in R&D What do you think are the major trends in drug discovery R&D? Biologics are booming. Small screens are better than large ones. Biochemical assays have the highest success rate. Think again. That is not what PerkinElmer found in a comprehensive survey of leaders at …
COVID-19 is a difficult disease to understand and treat. Using drugs that are already on the market was the quickest path forward to evaluate these compounds and possibly help patients now because novel drug development typically takes years. Scientists needed to evaluate the field of potential drugs-and fast. When a research team at the National …
Impaired glucose consumption is one of the principal markers for many disease conditions such as cancer, diabetes, obesity, and some neurologic disorders. Positron emission tomography (PET) is the most commonly used technique for imaging and quantifying glucose uptake. It has significant drawbacks for laboratory use, however, namely the short half-life of the reagent, the need …
