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Managing the data deluge of high-content screening workflows

Integral to many research and testing facilities are the high-content screening (HCS) technologies that continue to evolve alongside imaging and analysis systems. HCS platforms serve a multitude of purposes, from screening the effects of potential drug compounds on cellular processes to facilitating the study of complex biological pathways. Imaging experiments can yield valuable insights into …

Recent developments and novel strategies such as immunotherapies and targeted therapies have made significant advancements in cancer treatments. Long-term benefits have been demonstrated using these approaches, leading to multiple approvals from regulatory bodies. Sadly, only some treated patients develop an objective tumor response with long-term survival benefits. On top of that, the systemic delivery of …

Redefining precision medicine with real-time insights

Increasingly, we are realizing that every tumor is different, meaning that a one-size-fits-all approach to cancer treatment will be ineffective. Multiple techniques are needed to unpick the factors underlying tumor heterogeneity and to improve treatment efficacy. One notable technique is the utility of liquid biopsies to provide real-time insights into tumor evolution and treatment response. …

Exploring the role of radioligand binding assays in drug discovery.

In the early 1970s, Professor Solomon Snyder and colleagues reported a technique that enabled the identification of opiate receptors in the brain.1 This was the first discovery of its kind, providing direct evidence for drug receptors as molecular entities. Using radioactive ligand binding methods, Dr. Snyder’s team found that the receptors were highly concentrated in …

strategies for characterization of next-generation bispecific antibodies

The emergence of bispecific antibodies has been heralded as the fourth wave of biopharmaceutical innovation, providing opportunities to target two different antigens with a single therapeutic. For example, some bispecific antibodies can bind different antigens expressed on two different cell types, bringing those cells together as a more effective treatment for complex diseases. There are …

Cancer research has witnessed remarkable advancements in recent years, enabling scientists to understand many of the intricacies underlying this complex disease. One such breakthrough technology is fluorescence in vivo imaging, which utilizes fluorescent probes to detect specific oncological biomarkers and protease activity to drive the development of cancer therapies. By enabling noninvasive assessment of in …

Tuberculosis (TB) is a potentially lethal bacterial infection that spreads in the air from one person to another. Last year, the World Health Organization (WHO) reported that the number of people infected with Mycobacterium tuberculosis (Mtb), including drug-resistant strains, had risen globally for the first time in almost 20 years. The disease killed over 1.6 …

The Future of Precision Medicine: Integrating Functional Approaches for Better Outcomes

Precision medicine is an approach that considers patients’ individual differences in genes, environment, and lifestyle to personalize medical treatments. In the case of cancer, precision medicine involves the identification of specific molecular traits or mutations that drive tumor growth. This information is then used to tailor the treatment of each individual patient. “Every tumor is …

Overcoming Solid Tumor Treatment Hurdles With mRNA-based CAR T-cells

Over the last decade, chimeric antigen receptor (CAR) T-cell therapies have attracted growing interest for their potential to treat a wide range of cancers. To date, six CAR T-cell therapies have been approved by the FDA, all for the treatment of hematological malignancies such as leukemia and lymphoma. In contrast to the success of CAR …

Overcoming Throughput, Standardization, And Analysis Challenges for Human Midbrain Organoids

In recent years, interest in human three-dimensional (3D) organ-like microtissues called organoids has skyrocketed, with citations increasing exponentially in the scientific literature over the past decade. Organoids are structurally and cellularly complex, with functions which mimic their human organ counterparts. These characteristics give them distinct advantages over traditional two-dimensional (2D) monolayer cell systems, which do …

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